STUDY OF DOSAGE ADJUSTMENT OF ORAL ANTIDIABETIC DRUG IN TYPE II DIABETES MELLITUS PATIENTS WITH DISORDERS KIDNEY FUNCTION AT DR. SOEKARDJO TASIKMALAYA HOSPITAL

Diabetic nephropathy is one of the complications in DM that can end up becoming kidney failure. Nephropathy complications, if not handled properly, will lead to terminal chronic disease. One factors trigger diabetic patients long-term use oral anti-diabetic drugs. Therefore, proper dosage adjustment these antidiabetic drugs, which are excreted through kidneys, required. The purpose this study was determine whether dose received by type II with impaired renal function hospital appropriate or not. This research be carried out quantitatively and retrospectively collecting patient medical record data at hospital, then obtained analyzed descriptively calculating creatinine clearance using Cockcroft & Gault formula comparing it literature based on value clearance. sampling technique used purposive inclusion exclusion criteria determined researcher. diabetes mellitus dr. Soekardjo Tasikmalaya Hospital October–December 2020 who were treated insulin, I patients, incomplete laboratory data. Based has been conducted 35 samples, as many 25 people, 71.43 percent therapeutic doses accordance their conditions. Meanwhile, 10 28,57% a according condition.